胃癌患者血清中五种微量元素含量的分析

The Preliminary Analysis of the Five Trace Element Contents in the Serum in Patients with Gastric Carcinoma

报告１９８６年１２月～１９８９年３月间，用极谱法检测了胃癌患者５４例血清中锌、铜、钼、铬和硒等５种微量元素的含量，同时与８３名正常人和１８例胃良性疾病患者进行比较。结果分析发现，胃癌患者血清锌和硒的含量较正常人明显降低（Ｐ＜０，０１及Ｐ＜０．０５）；而血清铜及铜／锌比值较正常人非常显著升高（Ｐ＜０．０１）；血清钼和铬的变化与正常人差别不大（Ｐ＞０．０５），结合文献对上述变化的原因、因果关系及意义进行了初步讨论。另总结观察了１５例已行根治性胃大部切除后一年的患者血清锌、铜和硒的变化。发现其含量有较大变化并已接近于正常人的水平，就此提出了用术后各元素值的动态变化作为判断预后的设想。

It is reported that the five trace element contents (Zn. Cu. Cr. Mo and Se) in the serum were detected using the polarographic analysis method in 54 patients with gastric carcinoma,18 patients with benign gastricc disease and 83 normal controls, from Dec. 1986 to Mar. 1989. The results are as follow: the serum levels of the Zn and Se decreased (P<0.01 and P<0.05). the Cu level and the ratio of the Cu/Zn increased (P<0.01), Mo and Cr levels did not show significantly different compared with the normal controls. On the other hand, the serum levels of the Zn, Cu and Se in 15 patients (on whom radical gastrectomy were operated ) changed significantly and closed to the normal controls after one year. Depending upon the results. a presume is recommended that the changes of the trace element content in the serum could be as a prognostic sigh of patients with radical gastrectomy.