肾小球疾病时微量元素代谢的变化

Changes in Trace Element Metabolism During the Course of the Glomerular Disease

用发射光谱法测定了５５例广州地区居民患肾小球疾病时血清和头发中锌、铜、铁、钴、铬、锰含量．观察对象包括肾病综合征组１７例，肾炎组１７例，尿毒症组２１例．对照组为３０例健康人，其年龄、性别构成比、地区与观察组无显著位差异．结果经统计学检验发现肾病综合征组病人血清锌、铜、钴及头发锌、钴含量均明显下降，头发铜无明显变化．肾炎组血清钴、头发钴明显下降，血清辞、铜及头发锌、铜无明显变化．尿毒症组病人血清锌、头发锌、钴显著下降，血清钴、铜及头发铜无明显变化．肾炎组、肾病综合征组及尿毒症组病人血清及头发中铁、铬、锰均无明显变化．

We measured Zn、Cu、Fe、Co、Cr、Mn in serum and hair of 55 cases with glomerular diseases and 30 controls using ICP-AES.The patients were divided into 3 groups,including 17 patients in nephrotic syndrome group.17 patients in glomerulonephritis group,21 patients in uremia group.There were no significant differences in sex and age between each group of the patient, and the control. Compared with the control group,Zn、Cu、Co in serum and Zn、Co in hair decreased and Cu in hair didn't change significantly for nephrotic syndtome group;Co in serum and hair decreased and Zn,Cu in serum and hair didn't change for glomerulonephritis group; Zn in serum and hair and Co in hair decerased and Co, Cu in serum and Cu in hair didn't change significantly for uremia group. Fe,Cr,Mn in serum and hair didn't change in each group of patients.