胃癌患者与非癌对照血清微量元素含量对比研究

A Matched Study on Trace Element Content in the Serum in the Gastric Cancer Patients and Controls

在医院选择３３例经病理学诊断的胃癌患者及７９例非癌对照，测定其血清锌、铜、锰、钼、硒含量并进行对比分析。结果显示，胃癌患者血清铜含量显著低于对照组（Ｐ＜０．０５））；血清硒含量亦显著低于对照组（Ｐ＜０．００２）．曾报道，江西土壤有效钼含量与胃癌死亡率呈负相关．江西胃癌患者发钼含量显著低于非癌对照．硒是抗氧化剂和抗氧化酶的重要成分，在抑制自由基反应、清除过氧化物方面起重要作用．显然钼、硒与胃癌关系十分密切。缺乏钼、硒是造成胃癌发病率升高的危险因素。

The five trace element contents (Zn. Cu, Mn. Mo and Se) in the serum were detected in 33 patients with gastric cancer and 79 control'The results showed that the content of serum Se in the patients with gastric cancer was significant lower than that of the controls(P <0.002). The similar result was also detected in the serum Mo (P<O.05).Our group had reported the negative corelation between the effective Mo content in soil and the mortality rate of gastric cancer in Jiangxi province. Compared to the controls, the level of Mo was remarkable decrease in the hair of the patients with gastric cancer. It is well known that Se plays an important role in inhibitting free-radical reaction and eliminating superoxide. We suggested that the level of serum Mo and Se was corelative with the pathogenesis of gastric cancer. A lack of Mo and Se may cause the increasing of incidence rate of gastric cancer.