270株鲍曼不动杆菌的临床分布和耐药性分析

The Clinical Distribution and Drug Resistance of 270 Strains of Acinetobacter Baumannii

目的了解鲍曼不动杆菌的临床分布及耐药情况,为合理用药和有效防控院内感染提供依据。方法采用全自动微生物分析仪对2013-2015年送检的临床标本中分离的病原菌进行菌种鉴定和药敏试验,共鉴定出270株鲍曼不动杆菌,并得到相应的药敏试验结果,收集相关数据进行统计分析。结果 270株鲍曼不动杆菌80.11%来自痰液标本,科室分布以职业病科(25.56%)、姑息关怀科(21.85%)、老年科(20.74%)、肿瘤科(15.19%)和重症监护室(13.70%)为主;鲍曼不动杆菌的检出比例为12.57%,耐碳青酶烯类鲍曼不动杆菌占鲍曼不动杆菌的35.56%;对氨苄西林、头孢唑啉、呋喃妥因的耐药率超过了90%,对阿米卡星和复方新诺明的耐药率分别为12.22%和24.81%,其余抗菌药物的耐药率在35%~50%之间,对亚胺培南的耐药率也达到了35.56%。结论鲍曼不动杆菌对常用的13种抗菌药物呈现不同程度的耐药性,应加强鲍曼不动杆菌的耐药性监测,合理选用抗菌药物,预防与控制耐药菌的产生和医院感染暴发的出现。

Objective To investigate the clinical distribution and drug resistance of Acinetobacter Baumannii(AB)and provide the evidence for standard medication,nosocomial infection prevention and control.Methods After bacteria Isolated,they were separated from all kinds of clinical specimen from 2013 to2015.They were identified and performed drug sensitivity by automatic microorganism system.The data of the distribution and drug resistance of 270 strains of AB was collected for statistical analysis.Results There were 270 strains of AB mainly from the Department of Occupational Diseases(25.56%),Palliative Care(21.85%),Geriatrics(20.87%),Oncology(15.19%),and Intensive Care Unit(13.70%).The 80.11% samples were from sputum.The drug resistance rates were 12.22%for Amikacin,24.81%for Cotrimoxazole,35.56% for Imipenem and kinds of antibiotics were over 90% for Ampicillin,others were between 35%-50%.Conclusion The testing strains of AB had very different resistance to 13 kinds of antibiotics.It is essential to strengthen the drug resistance monitoring for AB and the usage of antibiotics rationally,to prevent and control the multidrug-resistance and nosocomial infection.