分别缩窄肝门静脉及肠系膜上动脉后肝动脉缓冲效应的实验研究

Experimental Study of Hepatic Arterial Buffer Response after Occluding Hepatic Portal Vein and Superior Mesentery Artery Subsequently

目的 探讨肝动脉缓冲效应产生机制。方法 2 0只猪麻醉后 ,肝门静脉 (PV)和肝动脉放置超声时差血流表后 ,对实验组 1 2只猪先行缩窄PV直接减少PV血流再缩窄肠系膜上动脉间接减少PV血流 ,对照组 8只猪同期测定肝动脉和PV血流。结果 直接缩窄PV组的PV血流由 (81 1 .30± 2 1 2 .4 4 )ml min下降为 (2 2 8.4 6± 87.32 )ml min(P <0 .0 1 ) ,肝动脉血流由 (1 31 .89± 4 8.5 2 )ml min增加为 (2 4 7.4 8± 5 2 .89)ml min(P <0 .0 5 )。缩窄肠系膜上动脉间接减少PV血流 ,由 (81 0 .5 7± 2 1 8.4 7)ml min下降为(2 1 3.74± 6 3.2 9)ml min(P <0 .0 5 )。肝动脉血流由 (1 4 3.6 1± 6 4 .6 3)ml min增加为 (2 5 7.4 3± 75 .38)ml min(P <0 .0 5 )。对照组与实验组的基础期PV血流和肝动脉血流差异无显著性 (P >0 .0 5 )。对照组在基础期和实验期的PV血流和肝动脉血流均无显著变化 (P >0 .0 5 )。结论 无论通过直接缩窄PV还是缩窄肠系膜上动脉间接降低PV血流 5 0 %以上 。

Objective To discuss the mechanism of hepatic arterial buffer response (HABR). Methods Blood flows of hepatic portal vein(PV)and hepatic artery (HA) were measured by ultrasonic transit time flowmenter in 20 anesthesia pigs.12 experimental pigs PV blood flows were reduced by occluding PV directly and then by occluding superior mesentery artery (SMA) indirectly.8 control pigs PV and HA blood flows were measured at same period. Results PV blood flow was reduced from (811.30±212.44)ml/min to (228.46±87.32) ml/min (P<0.01) in occluding PV directly,HA blood flow was increased at same time from (131.89±48.52) ml/min to (213.74±63.29) ml/min (P<0.05) .PV blood flow was reduced from (810.57±218.47) ml/min to (228.46±87.32) ml/min (P<0.01) in occluding SMA,HA blood flow was increased at same time from (143.61±64.63) ml/min to (257.43±75.38) ml/min (P<0.05) .Basic blood flow value of PV and HA were no significant difference in control group and experimental group (P>0.05) .Basic and experimental blood flow value of PV and HA were not changed significantly in control group. Conclusion HABR is presence when PV blood flow is reduced more than 50% basic value either occluding PV directly or occluding SMA indirectly.