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Wistar大鼠实验性自身免疫性脑脊髓炎模型的建立 被引量：2

Generation of Experimental Autoimmune Encephalomyelitis Model in Wistar Rats
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摘要 目的　研究用牛的髓鞘碱性蛋白 (MBP)诱导Wistar大鼠发生实验性自身免疫性脑脊髓炎 (EAE)。方法　一次性给Wistar大鼠双后腿足垫皮内注射牛MBP 福氏完全佐剂 (CFA)混合乳剂 ,同时辅以百日咳杆菌。结果　实验组大鼠全部发病 ,对照组无一发病。结论　用牛脊髓MBP的粗提品可成功地诱导Wistar大鼠发生EAE。 Objective To induce experimental autoimmune encephalomyelitis (EAE) in Wistar rat treated with myelin basic protein (MBP) purified from cattle spinal cord. Methods Wistar rats were immunized with both MBP in CFA and Bordetelle pertussis. Results All the experimental Wistar rats that treated with MBP and Bordetelle pertussis developed EAE but none of the control group. Conclusion EAE can be induced in less susceptible strains such as Wistar rats by a single intradermal injection of cattle's MBP in CFA.
作者 赵亚朴 黄庆军 王沛 刘颖 王憬 郝新玲
机构地区 白求恩军医学院
出处 《白求恩军医学院学报》 2003年第4期200-201,F002,共3页 Journal of Bethune Military Medical College
关键词 髓鞘碱性蛋白 大鼠 实验性自身免疫性脑脊髓炎 多发性硬化症 Myelin basic protein Rat Experimental autoimmune encephalomyelitis Multiple sclerosis
分类号 R744.3 [医药卫生—神经病学与精神病学] R744.51 [医药卫生—神经病学与精神病学]
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共引文献18

同被引文献14

  • 1董梅,刘瑞春,郭力,李春岩.Wistar大鼠实验性变态反应性脑脊髓炎的模型建立[J].脑与神经疾病杂志,2004,12(6):425-428. 被引量：19
  • 2李勇,郑荣远,李剑敏,王小同,邵蓓,金嵘,杨学志.实验性变态反应性脑脊髓炎大鼠模型的复制[J].中国病理生理杂志,2005,21(2):414-416. 被引量：16
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白求恩军医学院学报
2003年 第4期

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