Nd:YAP激光照射膀胱生物效应的实验研究

Experimental Study of Biological Effect on Canine Bladder by Nd:YAP Laser

目的 :研究Nd :YAP激光不同功率、照射时间对膀胱的生物效应。方法 :我们以犬作为实验对象 ,以不同功率、不同照射时间照射膀胱 ,以肉眼、光镜、电镜观察不同激光参数的生物学作用。结果 :Nd :YAP激光作用于膀胱 ,以热凝固效应为主 ,也有一定的消融作用。病理见全层击穿剂量 10W、6秒 ,2 0W、4秒。 30W、3秒。 4 0W、2秒。 5 0W及 6 0W、1秒。结论 :Nd :YAP激光作用于膀胱组织 ,以热凝固效应为主 ,也有一定的消融作用 ,功率 10W、时间小于 6秒 ;功率 2 0W时间小于 4秒功率 ;30W时间小于 3秒 ;功率 4 0W时间小于 2秒较安全 ,引起穿孔机率可减少。Nd :YAP激光的组织消融、热凝固作用与平均功率、照射时间成正相关。

Objective: To evaluate the influence of power, irradiation time on biological effect of Nd:YAP laser on canine bladder. Methods:The canine were studied .We irradiated the bladder in different power and different irradiation time. We observed the effects of ablation and thermal coagulation in different laser setting. We observed the damage with naked eye, micro and ultramicro structure. Results:The thermal coagulation effects is mostly and ablation effects is subordination on biological effect of Nd:YAP laser on canine bladder ,pathology vision thermal coagulation dose on perforation is10W、6s;20W、4s;30W、3s;40W、2s;50-60W、1s;the dose of whole audience wear through is 10W、6s;20W、4s;30W、3s;40W、2s;50-60W、1s.Conclusion: The thermal coagulation effects is mostly and ablation effects is subordination on biological effect of Nd:YAP laser on canine bladder. Better safety dose is power 10W、time less than 6s; power 20W、time less than 4s. power 30W、time less than 3s. power 40W、time less than 2s.The ablation and thermal coagulation effects of Nd:YAP laser on canine bladder is homocercal of power and time .