3-甲硫基-1-丙醇的合成研究

Study on Synthesis of 3-Methylthio-1-Propanol

研究了以 3 氯 1 丙醇和甲硫醇钠为原料 ,在相转移催化剂四甲基溴化铵的作用下 ,在 0℃下反应 1h ,然后升温至 30℃ ,并在此温度下反应 0 .5h ,合成了 3 甲硫基 1 丙醇 ,并用气相色谱、红外光谱和气质联用对其结构进行了确定。该方法工艺简单 ,条件温和 ,反应时间短 ,易于工业化 ,环境污染少 ,也适应于合成其他甲硫基化合物。

Methylthio-1-propanol was prepared by the reaction of 3-chloro-1-propanol with sodium thiomethoxide in the presence of phase transfer catalyst tetramethyl ammonnium bromide. At the beginning, the reaction lasted 1h at 0℃.Then the temperature was elevated to 30℃ and was kept for 30min.The structure of the product are confirmed by GC?IR and GC-MS.