SO_4^(2-)/TiO_2-WO_3催化合成苹果酯-B的研究

Synthesis of Fraistone by Using Solid Superacid SO_4^(2-) /TiO_2-WO_3

制备了固体超强酸SO2 4/TiO2 WO3 催化剂。以SO2 4/TiO2 WO3 为多相催化剂 ,对以乙酰乙酸乙酯和 1,2 丙二醇为原料合成苹果酯 B的反应条件进行了研究。实验表明 :固体超强酸SO2 4/TiO2 WO3 是合成苹果酯 B的良好催化剂 ,最佳反应条件为 :n(乙酰乙酸乙酯 ) :n(1,2 丙二醇 ) =1∶1.5 ,催化剂用量为反应物料总质量的 1.0 % ,环己烷为带水剂 ,反应时间 2 .0h ,反应温度 85～ 110℃。在上述条件下 ,苹果酯 B的收率可达 89.4 %。

Solid super acid SO 2- 4/TiO 2-WO 3 catalyst was prepared. Fraistone was synthesized from solid super acid SO 2- 4/TiO 2-WO 3. The result indicates that SO 2- 4/TiO 2-WO 3 prossesses a fairly high catalyst activity for the esterification reaction. The factors influencing the synthesis were discussed and the best conditions were found out. The optimum conditions are: molar ratio of ethyl acetoacetate to 1,2-propylene glycol was 1:1.5, the quantity of catalyst was equal to 1.0% of feed stocks, and the reaction time was 2.0 h. SO 2- 4/TiO 2-WO 3 was an excellent catalyst for synthesizing Fraistone and its yield can reach over 89.4%.