摘要
目的 :观察通心络对动脉粥样斑块VCAM -1和ICAM -1表达的影响。方法 :构建实验性家兔主动脉粥样硬化模型 ,随机抽签分组 ,通心络组 8只 ,高脂饮食组 8只。另设普通饲料喂养兔 5只组成空白对照组。采用免疫组织化学方法 ,测定各组VCAM -1、ICAM -1信号强度。结果 :通心络可一定程度减少动脉粥样斑块VCAM -1和ICAM -1的表达 ,通心络组VCAM -1和ICAM -1均低于高脂饮食组 (P <0 .0 5 )。结论 :通心络可延缓粥样斑块形成的进程。
Objective: To investigate the effects of Tongxinluo on the expression of vascular cell adhesion molecule-1(VCAM-1) and intercellular adhesion molecule-1(ICAM-1) in rabbit aortic atherosclerotic plaques. Methods: The rabbit aortic atherosclerotic model was developed by high cholesterol feeding. The protein levels of VCAM-1 and ICAM-1 in atherosclerotic plaques were studied by means of immunohistochemistry. Results: Tongxinluo decreased the protein levels of VCAM-1 and ICAM-1 in atherosclerotic plaques. Conclusion: Tongxinluo can decelerate the progression of atherosclerosis.
出处
《中西医结合心脑血管病杂志》
2003年第12期705-706,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
