抗帕颗粒对帕金森病模型大鼠黑质纹状体TH阳性神经元的影响

The Effect of Anti-Parkinson Potion on Substantia Nigra and Striatum TH-Positive Neurons in Parkinson Disease Rats

目的 :观察抗帕颗粒对帕金森病模型大鼠黑质纹状体TH阳性神经元的影响。方法 :帕金森病(PD)大鼠 80只 ,随机分为 4组 :对照组、美多巴组、抗帕颗粒组、抗帕颗粒联合美多巴组。于喂养 4个月后取黑质纹状体组织免疫组化染色 ,检测TH阳性神经元的分布、密度。结果 :美多巴组黑质TH阳性神经细胞及纹状体TH阳性终末较生理盐水组明显减少 ,而抗帕颗粒组增多 2 0 %～ 3 0 % ,联合组增多最显著达 40 %～5 0 %。结论 :抗帕颗粒可改善PD大鼠黑质纹状体TH阳性神经元的病理改变 ,抗帕颗粒联合美多巴治疗效果明显。

Objective: To observe the effects of anti-Parkinson potion on substantia nigra and striatum TH-positive neurons in Parkinson disease rats. Methods: 80 Parkinson disease (PD) rats were divided into 4 groups randomly,the control group (treated with normal saline), the group treated with Madopar, the group treated with anti-Parkinson potion ,and the group treated with both anti-Parkinson potion and Madopar. We performed immunohistochemistry to detect the distribution and the density of the TH-positive neurons and terminals 4 months after the beginning of treatments. Results:The number of the TH-positive neurons in substantia nigra and the TH-positive terminals in striatum in the Madopar group was less than that in the control group. Compared with the control group, the anti-Parkinson potion group and the combined group had more TH-positive neurons (increased 20%～30% and 40%～50% respectively). Conclusion:Anti-Parkinson potion can decrease the lesions of the TH-positive neurons in substantia nigra and striatum in PD rats, and the group treated with both anti-Parkinson potion and Madopar is better .