CD137L在多发性骨髓瘤中的表达及生物学功能

Expression and biological function of CD137L in multiple myeloma

收集多发性骨髓瘤(MM)和非血液系统疾病患者的骨髓血,分选出浆细胞。检测CD137配体(CD137L)患者骨髓血浆细胞中表达情况,以及CD137L在MM中对白介素10(IL-10)分泌和对MM细胞增殖的影响。结果显示:MM患者骨髓血浆细胞中CD137L表达水平呈高表达,下调其表达可促进IL-10分泌及增殖速度。

Bone marrow blood was collected from patients with multiple myeloma(MM)and non-hematological diseases,and plasma cells were isolated.The expression of CD137L in bone marrow plasma cells and the effect of CD137L in MM on interleukin-10(IL-10)secretion and MM cell proliferation were detected.The expression level of CD137L in bone marrow plasma cells of MM patients was high,and the down-regulation of its expression could promote the secretion and proliferation rate of IL-10.