溴虫腈中间体2-(对氯苯基)-5-三氟甲基吡咯-3-腈的合成进展

Progress in the Synthesis of Chlorfenapyr Intermediate 2-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

2-(对氯苯基)-5-三氟甲基吡咯-3-腈是制备溴虫腈和曲洛比利的关键中间体。以各类对氯苯基化合物为起始原料,对其合成概况进行了详细综述。

2-(4-Chlorophenyl)-5-(trifluoromethyl)-1 H-pyrrole-3-carbonitrile is a key intermediate in the preparation of Chlorfenapyr and Tralopyril.In this paper,various p-chlorophenyl compounds were used as starting materials,the synthesis of 2-(4-chlorophenyl)-5-(trifluoromethyl)-1 H-pyrrole-3-carbonitrile was reviewed in detail.