过渡金属催化的双齿导向基辅助的惰性C(sp^3)—H键芳基化

Transition-Metal-Catalyzed Arylation of Unactivated C(sp^3)—H Bonds Assisted by Bidentate Directing Groups

近年来,过渡金属催化的惰性碳氢键官能团化受到广泛关注,然而,C(sp3)—H键由于低极性、高解离能和低选择性,其选择性活化尤为困难.综述了过渡金属催化的双齿导向基辅助的C(sp3)—H键芳基化的最新研究进展,主要探讨了不同过渡金属催化下芳基化反应的底物范围、反应机理和合成应用.

Recently, transition-metal-catalyzed C-H functionalization has attracted tremendous interest as a valuable tool for carbon-carbon and carbon-heteroatom bond formation. However, due to the inertness of C(sp3)-H bonds and the difficulty to achieving high selectivity among the many chemically similar entities in a given molecule, the selective activation of C(sp3)-H bonds remains a great challenge. The recent progress in transition-metal-catalyzed arylation of unactivated C(sp3)-H bonds assisted by bidentate directing groups is reviewed, including the scope of reactions, mechanism and synthetic applications.