基于多米诺反应合成吲哚衍生物

Synthesis of Indole Derivatives via Domino Reactions

近年来,多米诺反应作为合成吲哚衍生物的有效方法已得到有机合成化学家的广泛关注.该反应过程中,不需改变反应条件和添加试剂,中间体也无需分离和提纯,实现了原子经济和环境友好的目标.通过过渡金属催化的多米诺反应合成吲哚衍生物,已经得到了深入研究并成为一种构筑该类杂环的有利工具.重点综述了近年来运用金属催化多米诺反应合成吲哚及其衍生物方面的研究进展,以催化剂的类型进行分类,介绍相关反应的特点和优势.

Domino reactions have received great attentions of organic chemist as an efficient protocol to synthesize indole derivatives. In this process, it is not required isolating or purifying the intermediates, changing the reaction condition and add-ing reagents. Transition metal-catalyzed domino reactions to synthesize indole derivatives have already been widely studied and become a powerful tool. In this paper, the progress of recent domino reactions applied to construct indole and its deriva-tives is reviewed, focusing on the transition metal-catalyzed domino reactions, and detailed analysis on the versatility and ap-plications.