严重创伤后凝血病的新疗法

Novel therapy of coagulopathy after severe trauma

目的探讨严重创伤后凝血病的早期诊断与新疗法治疗的疗效。方法选取我院2007年1月至2014年12月收治的严重创伤合并凝血病患者64例,外院紧急会诊救治患者9例作为研究对象。分为对照组和治疗组,对照组采用相关综合治疗,治疗组在综合治疗基础上,采用20AA高支链肝病复方氨基酸注射液（丰诺安）联用大剂量维生素B6新疗法。观察患者15 d死亡率的变化。结果与对照组比较,治疗组死亡率得到显著降低,大出血一般在1.572 h逐步得到控制,最快的1例在静脉输入1 h就明显控制了大出血,肝功能都有明显好转。结论在综合治疗基础上采用20AA高支链肝病复方氨基酸注射液（丰诺安）联用大剂量B6新疗法对救治严重创伤后凝血病患者效果明显。

Objective To explore novel therapy for patients with coagulopathy after severe trauma.Methods A total of 73 patients with traumatic coagulopathy from Affiliated Wujin Hospital of Jiangsu University and other hospitals were enrolled in the study and randomly divided into control group( n = 32)and therapy group( n = 41). The patients in control group received comprehensive treatment while the those in therapy group received combined use of compound amino acids and large doses of vitamin B6. The mortality rate during 15 days were analyzed. Results Compared with control group,the mortality rate in the therapy group was significantly lower( P < 0. 05). Under comprehensive treatments plus compound amino acids and large doses of vitamin B6,the bleeding was gradually under control within 1. 5-72 hours. The most quick speed for control of the bleeding was within 1 hour in one patient. The liver function was markedly improved. Conclusions Novel therapy combined with use of compound amino acids and large doses of vitamin B6 is feasible in the treatment of patients with severe traumatic coagulopathy.