炎症性肠病活动期患者肠黏膜白细胞介素-22结合蛋白及细胞因子表达研究

Study on the expression of IL-22 binding protein and cytokines in intestinal mucosa of patients with inflammatory bowel disease in active stage

目的研究炎症性肠病活动期患者肠黏膜白细胞介素-22结合蛋白(IL-22BP)及细胞因子的表达状况。方法选取2016年6月至2018年6月接诊的65例炎症性肠病患者进行研究。其中克罗恩病组(CD组)30例,溃疡性结肠炎组(UC组)35例。并选取同期接受治疗的结肠息肉患者30例作为对照组,检测分析三组肠黏膜IL-22BP及细胞因子表达水平。结果 CD组及UC组活动期患者的IL-22BP mRNA及蛋白水平均明显高于缓解期患者(P<0.05),且均明显高于对照组(P<0.05)。CD组及UC组活动期患者的IL-6、IL-8及TNF-α水平均明显高于缓解期患者(P<0.05),且均明显高于对照组(P<0.05)。结论炎症性肠病活动期患者肠黏膜IL-22BP及细胞因子表达水平明显升高,检测各项指标有助于预测患者活动期状况,值得临床推广应用。

Objective To study the expression of interleukin-22 binding protein(IL-22 BP) and cytokines in intestinal mucosa of patients with inflammatory bowel disease in active stage.Methods 65 patients with inflammatory bowel disease from June 2016 to June 2018 were selected for the study,with 30 cases in Crohn’s disease group(CD group) and 35 cases in ulcerative colitis group(UC group).At the same time,30 patients with colonic polyps were selected as control group.And then,the expressions of IL-22 BP and cytokines in the intestinal mucosa of the three groups were detected and analyzed.Results The levels of IL-22 BP in the CD group and the UC group in active stage were significantly higher than those in remission stage(P<0.05),and were all significantly higher than those in the control group(P<0.05).In addition,the levels of IL-6,IL-8 and TNF-α in active stage in the CD group and the UC group were significantly higher than those in remission stage(P<0.05),and were all significantly higher than those in the control group(P<0.05).Conclusion The expressions of IL-22 BP and inflammatory cytokines in intestinal mucosa of patients with inflammatory bowel disease in active stage increase significantly.The detection of various indicators is helpful to predict the status of patients in active stage,and it is worth popularizing in clinical practice.