经鼻持续正压通气治疗阻塞性睡眠呼吸暂停低通气综合征的疗效观察

Observation of curative effect of obstructive sleep apnea hypopnea syndrome treated by nasal continuous positive airway pressure

目的观察经鼻持续正压通气(CPAP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床疗效。方法选择2017年6月～2018年5月治疗的OSAHS患者104例作为研究对象,按随机数字表分为两组。对照组52例接受普通氧疗治疗,观察组52例接受CPAP治疗。对比观察两组最长呼吸暂停时间、睡眠评价量表(ESS)评分、炎症因子水平等。结果治疗前两组最长呼吸暂停时间、ESS评分对比,差异无统计学意义(P>0.05);与对照组相比,观察组治疗后最长呼吸暂停时间、ESS评分相对较低,差异有统计学意义(P<0.01)。治疗前两组CRP、IL-6水平对比,差异无统计学意义(P>0.05);治疗后与对照组相比,观察组CRP、IL-6水平较低,差异有统计学意义(P<0.01)。结论 OSAHS患者接受CPAP治疗有效性、可行性较高,利于改善患者睡眠状态及机体炎性反应,促进病情转归。

Objective To observe the clinical efficacy of nasal continuous positive airway pressure(CPAP) in the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 104 patients with OSAHS who were treated in our hospital from June 2017 to May 2018 were enrolled in the study.They were divided into two groups by random number table,with 52 cases in each group.The control group received general oxygen therapy,and the observation group received CPAP.And then,longest apnea time,Epworth sleepiness scale(ESS) scores and inflammatory factor levels were observed between the two groups.Results There was no statistically significant difference in the longest apnea time and ESS scores between the two groups before treatment(P>0.05).Compared with the control group,the longest apnea time and ESS score were relatively low in the observation group,difference was statistically significant(P<0.01).There was no statistically significant difference in the levels of C-reactive protein(CRP) and interleukin-6(IL-6) between the two groups before treatment(P>0.05).After treatment,the levels of CRP and IL-6 in the observation group were lower than those in the control group,difference was statistically significant(P<0.01).Conclusion The efficacy and feasibility of CPAP in patients with OSAHS are high,which is helpful to improve the sleep state and inflammatory response of the patients,and promote the outcome of the disease.