不同的红细胞制品输注治疗儿童重型地中海贫血的不良反应分析

Analysis of Adverse Reactions in Children with Severe Thalassemia Treated with Different Red Blood Cell Products

目的:探究不同的红细胞制品输注治疗儿童重型地中海贫血的不良反应。方法:选取笔者所在医院儿童重型地中海贫血96例,随机数字表法分为A组、B组、C组。A组给予普通红细胞输注,B组给予年轻红细胞输注,C组给予去白红细胞输注。对比三组不良反应发生情况及治疗前后检测三组T细胞亚群(T3、T4、T4/T8)、自然杀伤细胞(NK)细胞活性。结果:B组、C组FNHTR、输血性铁过载、免疫介导的输血不良反应发生率较A组低(P<0.05);治疗后B组、C组T3、T4、T4/T8、NK细胞活性较治疗前高(P<0.05);治疗后B组、C组T3、T4、T4/T8、NK细胞活性较A组高(P<0.05);输注后B组、C组Hb提升量高于A组(P<0.05)。结论:儿童重型地中海贫血采用年轻红细胞输注或去白红细胞输注治疗,可降低不良反应发生率,改善机体细胞免疫功能,提高输注效果。

Objective:To investigate the adverse reactions of different red blood cell products infusion for the treatment of severe thalassemia in children.Method:Ninety-six patients with severe thalassemia in our hospital were enrolled in this study.The random number table method was divided into group A,group B and group C.Group A was given a normal red blood cell transfusion,group B was given a red blood cell transfusion,and group C was given a white blood cell infusion.The activity of the three groups of T cells(T3,T4,T4/T8)and natural killer cells(NK)were compared before and after treatment.Result:The incidence of FNHTR,transfusion iron overload and immune-mediated transfusion adverse reactions in group B and C were lower than those in group A(P<0.05).The levels of T3,T4,T4/T8 and NK cell activities in group B and C after treatment were higher than those before treatment(P<0.05).The levels of T3,T4,T4/T8 and NK cells in group B and group C were higher than those in group A after treatment(P<0.05).After treatment,the increase of Hb in group B and group C was higher than that in group A(P<0.05).Conclusion:Children with thalassemia major are treated with young red blood cell transfusion or white blood cell infusion,which can reduce the incidence of adverse reactions and improve the cellular immune function,and improve the infusion effect.