摘要
目的:探讨多奈哌齐治疗假性痴呆伴发认知障碍患者的临床效果。方法:选取假性痴呆伴发认知障碍患者60例,按照随机数字表法,将其分为对照组(n=30)和观察组(n=30)。对照组采用阿米替林开展治疗,观察组在阿米替林治疗基础上加用多奈哌齐开展治疗,比较两组简易精神状况检查表(MMSE)、韦氏成人智力量表(WAIS-RC)及蒙特利尔认知评估量表(MoCA)评分。结果:相较于对照组,观察组治疗后的MMSE、WAISRC及MoCA均更高,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:多奈哌齐应用于治疗假性痴呆伴发认知障碍患者的临床疗效确切,安全性高。
Objective:To explore the clinical effect of Donepezil on patients with pseudodementia with cognitive impairment.Method:A total of 60 patients with pseudodementia complicated with cognitive impairment were selected and divided into control group(n=30) and observation group(n=30) according to the random number table.The control group was treated with Amitriptyline,and the observation group was treated with Donepezil on the basis of Amitriptyline.The two groups were compared with the simple mental status checklist(MMSE),the Wechsler adult intelligence scale(WAIS-RC),and the Montreal cognitive assessment scale(MoCA) score.Result:Compared with the control group,MMSE,WAIS-RC and MoCA were higher in the observation group after treatment,with statistically significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Donepezil is effective and safe in treating patients with pseudodementia with cognitive impairment.
作者
郝世胜
HAO Shisheng(Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine,Xiangyang 441000,China)
出处
《中外医学研究》
2019年第7期15-16,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
假性痴呆
认知障碍
机体
多奈哌齐
Pseudodementia
Cognitive impairment
Organism
Donepezil