无创辅助通气在新生儿监护病房的临床应用观察

Effect Observation of Non-invasive Mechanical Ventilation in Intensive Care Unit Neonates

目的:观察在新生儿监护病房开展无创辅助通气的临床效果。方法:选取笔者所在医院2017年1月-2018年12月新生儿监护病房收治的52例呼吸窘迫综合征患儿,随机分为对照组(n=26,采取固尔舒联合常规机械通气治疗)与观察组(n=26,固尔舒联合经鼻正压辅助通气治疗),对两组临床疗效及相关指标进行观察。结果:观察组有效率与对照组比较差异无统计学意义(P>0.05);观察组患儿住院时间、通气时间均较对照组明显要短(P<0.05);在治疗前,两组患儿动脉血气指标比较差异无统计学意义(P>0.05),治疗12、24 h,两组患儿Pa O2/Fi O2、Pa O2和p H值均较治疗前明显提升,Pa CO2值出现下降,差异有统计学意义(P<0.05),在同一时间点,两组各项动脉血气指标比较差异无统计学意义(P>0.05);在并发症发生率上,观察组较对照组明显要低(P<0.05)。结论:在新生儿监护病房中对呼吸窘迫患儿采取无创辅助通气,疗效显著,且并发症少,值得推广使用。

Objective:To study the clinical effect of non-invasive mechanical ventilation in intensive care unit neonates.Method:From January 2017 to December 2018,52 respiratory distress syndrome(RDS) neonates treated in ICU were selected and randomly assigned to the control group(n=26) and the observation group(n=26).The control group was served as Curosurf plus conventional mechanical ventilation.The observation group was served as Curosurf plus nasal intermittent positive pressure ventilation.The clinical effect and indicators were probed.Result:The effective rate between group was not significantly different(P>0.05),the hospitalization time and ventilation time in the observation group was shorter than control group(P<0.05),before treatment,arterial blood gas indicators between groups were basically consistent(P>0.05),after 12 h and 24 h of treatment,the values of PaO2/FiO2,PaO2 and pH for two groups were sharply increased while the values of PaCO2 were sharply declined(P<0.05),at the same time point,arterial blood gas indicators between groups were not significantly different(P>0.05),the complication rate in the observation group was lower than control group(P<0.05).Conclusion:The non-invasive mechanical ventilation has an obvious effect in RDS neonates,can reduce the complication rate.It is worthy of clinical promotion and application.