胺碘酮联合美托洛尔对冠心病心律失常的疗效及心率变异性的影响

Effect of Amiodarone Combined with Metoprolol on Coronary Heart Disease Arrhythmia and Influence on Heart Rate Variability

目的:分析冠心病心律失常治疗中胺碘酮联合美托洛尔的疗效及心率变异性(HRV)的影响。方法:选取73例冠心病心律失常患者随机分为对照组(35例,基础治疗+胺碘酮)、观察组(38例,对照组治疗方案+美托洛尔)。比较用药前后两组的HRV指标,对比两组的临床疗效及副作用。结果:用药前两组低频功率(LF)、高频功率(HF)、极低频功率(VLF)、NN间期标准差(SDNN)、NN间期标准差的均值(SDNNI)、相邻NN间期差>50 ms的心搏数百分比(PNN50)比较差异无统计学意义(P>0.05),用药后两组均显著提高,且观察组显著高于对照组,差异均有统计学意义(P<0.05);观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);两组副作用发生率比较差异无统计学意义(P>0.05)。结论:冠心病心律失常治疗中胺碘酮联合美托洛尔可改善患者HRV指标,提升临床疗效,且不会造成副作用的明显增多。

Objective:To analyze the efficacy of Amiodarone combined with Metoprolol in the treatment of arrhythmia in coronary heart disease and its effect on HRV.Method:A total of 73 patients with coronary heart disease and arrhythmia were randomly divided into control group(35 cases,basic treatment+Amiodarone)and observation group(38 cases,control group treatment+Metoprolol).The heart rate variability index between the two groups before and after medication,the clinical efficacy and side effects of the two groups were compared.Result:There were no significant differences in low frequency power(LF),high frequency power(HF),very low frequency power(VLF),NN interval standard deviation(SDNN),NN interval standard deviation(SDNNI)and adjacent NN interval difference>50 ms between the two groups before treatment(P>0.05),which were significantly increased after treatment(P<0.05),of which the observation group were significantly higher than those of the control group(P<0.05).The total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in the incidence of side effects between the two groups(P>0.05).Conclusion:Amiodarone combined with Metoprolol in patients with coronary heart disease arrhythmia can improve the heart rate variability index and improve clinical efficacy without causing a significant increase in side effects.