脑白质疏松症与认知功能障碍的相关性分析

Analysis of the Correlation Between Leukoaraiosis and Cognitive Impairment

目的:探讨脑白质疏松症与认知功能障碍的相关性。方法:选择2016年1月-2018年12月笔者所在医院收治的脑白质疏松症患者120例,采用Aharon-peretz标准将患者按照病情由轻到重分为A组(1级,n=30)、B组(2级,n=30)、C组(3级,n=30)、D组(4级,n=30),比较四组认知功能。结果:A组M MSE、MoCA、BI评分均高于B、C、D组,Hachinski缺血量表评分明显低于B、C、D组(P<0.05)。脑白质疏松症患者病情程度与认知障碍具有正相关性[OR=5.721,95%CI=(2.164,16.827),P<0.01]。结论:脑白质疏松症病情程度与认知功能障碍呈正相关性,当脑白质疏松症患者病情加重时,认知功能障碍会随之加剧。因此,可将认知功能作为评估脑白质疏松症患者病情的参考依据。

Objective:To explore the correlation between leukoaraiosis and cognitive impairment.Method:A total of 120 patients with leukoaraiosis admitted to our hospital from January 2016 to December 2018 were selected,and patients were divided into four groups according to the Aharon-peretz criteria:the group A(grade 1,n=30),the group B(grade 2,n=30),the group C(grade 3,n=30),and the group D(grade 4,n=30).Result:MMSE score,MoCA score,BI score were higher than those of the group B,C and D,and Hachinski ischemia scale score in the group A was significantly lower than those of the group B,C and D(P<0.05).There was a positive correlation between the severity of leukoaraiosis and cognitive impairment[OR=5.721,95%CI=(2.164,16.827),P<0.01].Conclusion:There is a positive correlation between the severity of leukoaraiosis and cognitive impairment.When the condition of leukoaraiosis is aggravated,the cognitive impairment of patients is aggravated seriously.Cognitive function can be used as a reference for evaluating the condition of patients with leukoaraiosis.