STEMI患者PCI术后应用替罗非班对心功能及血清前白蛋白水平的影响

Effects of Tirofiban on Cardiac Function and Serum Prealbumin Level in Patients with STEMI after PCI

目的:探究ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入术(PCI)后应用替罗非班对心功能及血清前白蛋白水平的影响。方法:选择2017年1月-2018年12月笔者所在医院收治的98例STEMI患者进行研究。按照随机数字表法将其分为观察组及对照组,每组49例。两组患者均行PCI术及常规抗血小板治疗,观察组在此基础上给予替罗非班治疗,比较两组患者手术前后血流分级,左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)等心功能参数,血清前白蛋白水平及不良心血管事件发生情况。结果:术后观察组血流分级显著优于对照组,差异有统计学意义(P<0.05)。术后1、3 d时两组患者血清前白蛋白均显著降低(P<0.05),术后3 d时观察组血清前白蛋白水平显著高于对照组,差异有统计学意义(P<0.05)。术后3个月时观察组LVEF水平显著高于对照组(P<0.05),LVESD、LVEDD水平显著低于对照组,差异均有统计学意义(P<0.05)。观察组不良心血管事件发生率为2.04%,对照组不良心血管事件发生率为6.12%,组间比较差异无统计学意义(P>0.05)。结论:STEMI患者PCI术后应用替罗非班可显著改善术后血流分级及心功能水平,减缓血清白蛋白水平的下降。

Objective:To investigate the effects of Tirofiban on cardiac function and serum prealbumin level in patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Method:A total of 98 patients with STEMI admitted in our hospital from January 2017 to December 2018 were selected for the study.They were divided into observation group and control group by random number table method,with 49 cases in each group.Patients in both groups underwent PCI and routine antiplatelet therapy,and the observation group received Tirofiban on this basis.The blood flow grading,cardiac function parameters such as left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD),serum prealbumin levels and adverse cardiovascular events were compared between the two groups.Result:After surgery,the blood flow grading of the observation group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).The serum prealbumin levels were significantly decreased in the two groups at 1 and 3 days after surgery(P<0.05).The serum prealbumin level of the observation group was significantly higher than that of the control group at 3 days after surgery,the difference was statistically significant(P<0.05).LVEF level in the observation group was significantly higher than that in the control group at 3 months after surgery(P<0.05),and LVESD and LVEDD levels were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse cardiovascular events was 2.04%in the observation group and 6.12%in the control group,there was no significant difference between the two groups(P>0.05).Conclusion:The application of Tirofiban for patients with STEMI after PCI can significantly improve postoperative blood flow grading and cardiac function,and slow down the decline of serum albumin level.