暴发性肝功能衰竭大鼠胃肠推进运动的变化

Alterations of Gastrointestinal Propulsive Motility in Rats With Fulminant Hepatic Failure From Thioacetamide

应用硫代乙酰胺灌胃复制暴发性肝功能衰竭大鼠模型,测定了大鼠胃肠推进运动的变化,结果:暴发性肝功能衰竭大鼠胃肠推进运动较正常大鼠显著减弱。肌肉注射胃复安、西沙必利或红霉素可显著增强肝功能衰竭大鼠的胃肠推进运动,这一效应可被皮下注射阿托品所完全阻断。表明这些药物可能通过迷走神经而使胃肠推进运动增强。

Changes of gastrointestinal propulsive motility were measured in rats of experimental fulminant hepatic failure due to thioacetamide. The results show that their gastrointestinal propulsive motility not only significantly decreased, compared with that of normal rats, but also strenthened followings injection of metocropramide, cisapride or erythromycin into the muscles. These effects, however, were abolished by injection of atropine into the hypoderm. Therefore, such drugs may enforce the gastrointestinal propulsive mutility by way of vagus nerves.