肺结核病人异烟肼乙酰化速率与疗效和副作用的关系

Acetylation of Isoniazid in Pulmonary Tuberculosis

对286人INH乙酰化速率的测定,快乙酰化者152人;中速乙酰化者71人;缓慢乙酰化者63人;分别为53.15％;24.82％;22.03％。运用含INH周二次方案治疗涂阳肺结核,快速乙酰化者疗末痰菌阴转率为98.46%;缓慢、中间乙酰化者为96.30％,两者无显著性差异。(P>0.05)用此方案均未合用维生素B_6,末见发生末稍神经炎。

Rate of acetylation of isonlazid was measured in 286 adults, of whom 152 were rapid acetylators (53.15%), 71 middle (24. 82%), and 63 slow(22. 03%).Treatment of the smear-postive tuberculosis with INH twice weekly resulted in a 98. 46% negative conversion rate in the rapid, a 99. 30% one in both the middle and slow, with no significant differences between the two (P > 0. 05). During the treatment, no vitamin B6 was administered and no peripheral neuritis occurred.