Curcuma′s extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin,proliferating cell nuclear antigen and Toll-like receptor expression

OBJECTIVE Recently,some reports show that curcuma has a good curative effect on the treatment of psoriasis;while curcuma has many components,so the present study was designed to investigate the effective parts of curcuma on treatment of psoriasis,in addition,we will explore the mechanisms of curcuma therapeutic effect.METHODS First,we observed that curcuma′s extractions effect on mitosis of mouse vaginal epithelial cells;then psoriasis like was induced by wiping imiquimod in the surface of the binaural dorsal skin of the animal,the score of skin damage was measured on days 7 and 14;in order to explore the mechanisms of curcuma’s extractions on psoriasis,immune factors expression(CK14,CK16,CK17,PCNA,TLR-2,TLR-4,TLR-9)was determined in propranolol induced psoriasis like.RESULTS Curcuma′s extraction prohibited the mitosis of mouse vaginal epithelial cells;curcuma’s extractions produced a significant and dose dependent inhibition of psoriasis during the entire duration of the study in imiquimod induced psoriasis like;and the expression of immune factors(CK14,CK16,CK17,PCNA,TLR-2,TLR-4,TLR-9)was also found to be less in the curcuma′s extraction treated group as compared to control.CONCLUSION We believe that the curative effectof curcuma’sextraction may due to its inhibition effect on the expression of immune factors.Our results contribute towards validation of curcuma in the treatment of psoriasis and other joint disorders.