衰老过程中炎症相关的信号传导通路研究进展

Research progress in signal transduction pathways associated with inflammation in aging process

衰老是一个复杂的过程,是多因素共同作用的结果。越来越多的研究表明,炎症相关信号传导通路对衰老过程的调节具有重要作用,其中抑制NF-κB、西罗莫司(雷帕霉素)靶蛋白(TOR)、晚期糖基化终末产物受体(RAGE)和胰岛素信号通路,及激活抗衰老酶sirtuins家族成员沉默信息调节因子1(Sirt1)等均能不同程度地调控炎症,延缓衰老。NF-κB作为炎症信号通路的分子开关,能与其他通路相互关联,在调控炎性衰老方面起着核心作用。本文将对NF-κB、抗衰老酶蛋白家族、TOR、RAGE、Notch受体和胰岛素等炎症相关信号通路在调控衰老过程中的作用进行综述。

Aging is a very complex process,resulting from many factors. More and more studies show that the signal transduction pathways associated with inflammation play important roles in regulation of aging process. The inhibitions of NF-κB,target of sirolimus(Rapamycin)(TOR),receptor for advanced glycation end products(RAGE),insulin receptor signal pathway,and the activation of Sirt1 of sirtuins family could regulate inflammation and delay aging in varying degrees. NF-κB signaling pathway,a molecular switch of inflammation,is associated with other inflammation pathways,and plays a central role in the regulation of inflamm-aging. This article wil review the roles of NF- κB,sirtuins family,TOR,RAGE,Notch and insulin pathways in regulation of aging process.