网络药理学在中药“同病异治”和“异病同治”研究中的应用

Application of network pharmacology in study of "the same disease with different treatments" and "different diseases with the same treatment" of traditional Chinese medicine

中药具有'多成分-多靶点-多途径'的作用特点,在预防和治疗复杂性疾病过程中具有明显优势,尤其是在'同病异治'和'异病同治'方面,但目前仍存在药效物质基础不清楚、作用机制不明确等问题。网络药理学是在系统生物学与多向药理学的基础上提出的一种新思想、新策略,它系统综合地观察药物对疾病网络的干预和影响,特别适合复杂中药体系的研究。

TCM with the characteristics of"multi-component-multi-target-multi-pathway",whose advantage in the prevention and treat?ment of complex diseases is obvious,has been applied in the study of"the same disease with different treatments"and"different diseases with the same treatment".However,pharmacodynamic substances and the mechanisms remain largely unknown.Network pharmacology is a new idea and strategy based on systems biology and multidirectional pharmacology.It systematically observes the intervention and influence of drugs on disease networks,which is especially suitable for the study of complex TCM systems.