作用于自噬的药物可能对肿瘤转移发挥治疗作用

Medicines for autophagy may be used to treat tumor metastasis

随着人类生活方式的改变、环境污染的加重和人口老龄化的加剧,恶性肿瘤的发病率和死亡率越来越高。转移是恶性肿瘤最致命的特征,占肿瘤相关死亡的90%以上[1]。自噬是一种进化相当保守的生物过程,指的是真核细胞的细胞器与各种物质被包裹在磷脂双分子层内形成自噬体,进而运送到溶酶体进行降解,达成各成分的回收利用。

With the change of human lifestyle,the aggregation of pollution and the aging of the population,the incidence and mortality of malignant tumors are increasing.Metastasis is the most deadly feature of malig?nant tumors,accounting for more than 90%of tumor-related death[1].Autophagy is a quite conser?vative biological process in evolution.It means that the eukaryotic cell organelles and various substances are entrapped in the phospholipid bilayer to form autophagosomes,which are then transported to lysosomes for degradation.Autophagy plays a crucial role in the regulation of cell growth and homeostasis[2].There are numerous internal and external factors that induce autophagy,including malnutrition,reactive oxygen species,hypoxia,and drugs.