摘要
多柔比星(DOX)作为广谱抗肿瘤药物,临床中用于多种癌症的治疗。然而,DOX在使用时可剂量依赖性诱导骨骼肌功能障碍,致使癌症患者生存质量明显下降。本文通过对DOX毒性作用、DOX诱导骨骼肌功能障碍特点以及DOX诱导骨骼肌功能障碍的相关发生机制进行综述,重点对氧化应激、Ca2+超载、线粒体能量代谢失调、细胞自噬与凋亡、一氧化氮浓度和氨基酸代谢及肌源性调节因子表达等病理机制进行总结,并对未来研究方向予以展望,希望为临床深入研究DOX肌肉毒性作用提供理论依据。
Doxorubicin(DOX)is a widely used clinical anti-tumor drug for cancer.Unfortunately,DOX can also cause skeletal muscle dysfunction in a dose-dependent manner,leading to a significant decline in the quality of life of cancer patients.In this paper,we summarize the toxic effects of DOX,the characteristics of DOX-induced skeletal muscle dysfunction and its related mechanisms.We focus on pathological mechanisms,including oxidative stress,Ca2+overload,mitochondrial energy metabolism disorder,autophagy and apoptosis,nitric oxide concentration and amino acid metabolism and myogenic regulatory factor expression.Research prospects are outlined.It is expected to provide a theoretical basis for the clinical study of DOX toxicity.
作者
李爱
魏安奎
徐昕
LI Ai;WEI An-kui;XU Xin(Department of Rehabilitation,Childern′s Hospital of Shanghai Jiao Tong University,Shanghai Children′s Hospital,Shanghai200062,China;School of Kinesiology,Shanghai University of Sports,Shanghai200438,China;Department of ExerciseRehabilitation,Shanghai University of Sports,Shanghai200438,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2019年第4期314-320,共7页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(81370197)~~
关键词
多柔比星
骨骼肌功能障碍
氧化应激
线粒体
自噬
doxorubicin
skeletal muscle dysfunction
oxidative stress
mitochondrial
autophagy