前列腺癌患者去势治疗后认知功能状况调查分析

目的探讨前列腺癌患者行双侧睾丸切除术后认知功能状况及其影响因素。方法对2014年1月至2016年1月转至我科前列腺癌患者分2组,其一为双侧睾丸切除术45例(去势组),另一组为前列腺癌根治术31例(根治组),采用蒙特利尔认知功能评估量表(Mo CA)、社会支持评定量表(SSRS)进行调查问卷,并收集两组患者术后6个月的相关数据进行分析。结果去势组中认知功能出现障碍者32人,占71.1%(32/45),根治组中认知功能出现障碍者14人,占45.2%(14/31),两组在患者年龄、独居情况、社会支持情况及术后睾酮下降者所占比例均有统计学差异性(P<0.05);两组术后睾酮水平、注意力、延迟记忆评分及Mo CA总分上均有显著性差异(P<0.05)。结论前列腺癌患者行双侧睾丸切除术后6个月认知功能障碍发生率较高,患者年龄、社会支持情况及术后睾酮水平与认知功能障碍发生关系密切。

objective to detect the impairment and affecting factors of cognition in prostate patients who received bilateral orchiectomy,and provide the new thoughts for evaluation and prevention of impairment cognition in the early stage. Methods the prostate patients from January in 2014 to January in 2016 were divided into two groups. 45 patients in Group one were treated with bilateral orchiectomy,and 31 patients in group two were treated with radical prostatectomy. Montreal cognitive assessment scale( Moca) and SSRS were used to analysis data in 6 months after operation. Results 32 patients in group one had impairment of cognition,and 14 patients had impairment in group two. There were significantly differences in the age,alone living,social support,and teststerone level between two groups,( P < 0. 05). There were significantly differences in the teststerone level,attention,delayed memory scores,and Moca scores between two groups,( P < 0. 05). Conclusions the prostate patients who received bilateral orchiectomy may have higher incidence of impairment of cognition. The age,social support,and teststerone level maybe the affecting factors.