曲普瑞林注射剂联合来曲唑辅助手术治疗子宫内膜异位症的临床效果

Clinical effect of triptorelin injection combined with letrozole assisted surgery in the treatment of endometriosis

目的探讨曲普瑞林注射剂联合来曲唑辅助手术治疗子宫内膜异位症的临床效果。方法将我院2016年6月至2017年6月收治的80例子宫内膜异位症患者随机分为观察组和对照组,各40例。两组患者均行保留生育功能的腹腔镜手术。对照组于术后月经来潮第1天肌肉注射曲普瑞林;观察组在对照组治疗基础上,于术后第5天开始口服来曲唑片。两组均连续治疗6个月。比较两组的临床疗效、妊娠率、治疗前、后血清CA125、CA199、EMAb水平及不良反应发生情况。结果观察组的治疗总有效率为95.00%,显著高于对照组的75.00%(P<0.05);观察组的妊娠率为57.50%,显著高于对照组的30.00%(P<0.05);治疗后,两组患者血清CA125、CA199及EMAb水平均显著降低,且观察组明显低于对照组(P<0.05)。结论子宫内膜异位症患者术后采用曲普瑞林注射剂联合来曲唑进行巩固治疗,临床效果较好,其作用机制可能与降低血清CA125、CA199和EMAb水平有关,且安全性较高,值得临床推广和应用。

Objective To investigate the clinical effect of triptorelin injection combined with letrozole assisted surgery in the treatment of endometriosis. Methods Eighty patients with endometriosis admitted in our hospital from June 2016 to June2017 were randomly divided into observation group and control group, with 40 cases of each group. Patients in both groups underwent laparoscopic surgery with fertility preservation. The control group received intramuscular injection of tripraline on the first day of postoperative menstruation. On the basis of treatment in the control group, the observation group began to take letrozole tablets orally on the 5 th day after surgery. Both groups were treated continuously for 6 months. The clinical efficacy, pregnancy rate, serum CA125, CA199 and EMAb levels before and after treatment and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 95.00%, which was significantly higher than 75.00% in the control group(P <0.05). The pregnancy rate of the observation group was57.50%, which was significantly higher than 30.00% in the control group(P<0.05). After treatment, serum CA125, CA199 and EMAb levels in the two groups significantly reduced, and those in the observation group were significantly lower than the control group(P <0.05). Conclusion The clinical effect of triptorelin combined with letrozole assisted surgery in the treatment of endometriosis is good, and the mechanism may be related to lowering serum CA125, CA199 and EMAb levels,which is safty and worthy of clinical promotion and application.