熊去氧胆酸联合疏肝利胆汤加减治疗早、中期原发性胆汁性肝硬化的效果

Effect of ursodeoxycholic acid combined with modified Shugan Lidan decoction in the treatment of early and middle stage primary biliary cirrhosis

目的探讨熊去氧胆酸联合疏肝利胆汤加减治疗早、中期原发性胆汁性肝硬化(PBC)的效果。方法将我院102例早、中期PBC患者随机分为对照组(熊去氧胆酸)和观察组(熊去氧胆酸联合疏肝利胆汤加减),各51例。比较两组的治疗效果。结果观察组的显效率、治疗总有效率、血清VEGF、ALP、GGT、ALT、AST、TBIL、HA、Ⅳ-C和PC-Ⅲ水平均优于对照组(P<0.05)。结论熊去氧胆酸联合疏肝利胆汤加减治疗早、中期PBC效果肯定,值得应用推广。

Objective To investigate the effect of ursodeoxycholic acid combined with modified Shugan Lidan decoction in the treatment of early and middle stage primary biliary cirrhosis(PBC). Methods A total of 102 patients with early and middle stage PBC in our hospital were randomly divided into control group(ursodeoxycholic acid) and observation group(ursodeoxycholic acid combined with modified Shugan Lidan decoction), with 51 cases in each group. The treatment effects of the two groups were compared. Results The effectiveness rate and total effective rate of treatment, serum levels of VEGF,ALP, GGT, ALT, AST, TBIL, HA, IV-C and PC-Ⅲ in the observation group were better than those in the control group(P<0.05). Conclusion Ursodeoxycholic acid combined with modified Shugan Lidan decoction has definite effect on PBC in the early and middle stages, which is worthy of application and promotion.