强直性脊柱炎患者外周血中TNF-α、IL-17、IL-23、IL-33水平检测及其与病情的相关性分析

Ankylosing spondylitis patients' Peripheral blood TNF- α,IL-17,IL-23,IL-33 content and their relationship with disease condition

目的分析强直性脊柱炎患者外周血中肿瘤坏死因子-α(TNF-α)、白介素-17(IL-17)、白介素-23(IL-23)、白介素-33(IL-33)水平及其与病情的相关性。方法选择2012年11月至2014年11月接受住院治疗的强直性脊柱炎患者78例作为研究对象,另取67例同期在本院进行健康体检的正常人作为正常对照组,对比两组血清TNF-α、IL-17、IL-23、IL-33含量,疾病活动性因子红细胞沉降率(ESR)、C反应蛋白(CRP)水平,进一步分析TNF-α、IL-17、IL-23、IL-33含量与ESR、CRP水平的相关性。结果(1)研究组患者的血清TNF-α、IL-17、IL-23、IL-33含量明显高于对照组(P<0.05);(2)研究组患者的血清ESR及CRP水平显著高于正常对照组(P<0.05);(3)强直性脊柱炎患者中,外周血TNF-α、IL-17、IL-23、IL-33含量与疾病活动性因子ESR、CRP水平呈正相关(P<0.05)。结论强直性脊柱炎患者外周血中TNF-α、IL-17、IL-23、IL-33水平显著上升,且其幅度与疾病活动性呈正相关,可以对疾病的严重度及治疗效果做出客观评估。

Objective To analyze Ankylosing spondylitis patients′Peripheral blood TNF - α,IL - 17,IL - 23,IL - 33 content and their relation-ship with disease condition. Methods 78 cases of Ankylosing spondylitis between November 2012 to November 2014 in our hospital were choosed as research subjects,at same time choosed 67 cases received healthy test in our hospital as normal control group,compared two groups patients′serum TNF - α,IL - 17,IL - 23,IL - 33 contents,disease activity factor ESR ,CRP levels,relationship between TNF - α,IL - 17,IL - 23,IL - 33 con-tent and ESR,CRP level. Results (1)Observation group patients′serum TNF - α,IL - 17,IL - 23,IL - 33 levels were significantly higher than con-trol group(P < 0. 05);2)Observation group patients′ serum ESR and CRP levels were significantly higher than normal control group(P < 0. 05);(3) Observation group patients serum TNF - α,IL - 17,IL - 23,IL - 33 levels had positive relationship with ESR,CRP levels(P < 0. 05). Conclusion Ankylosing spondylitis patients TNF - α,IL - 17,IL - 23,IL - 33 contents increased,has positive relationship with disease activity indicators,can make an objective assessment of the severity and treatment for disease.