期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

氧化三甲胺与炎症性疾病 被引量：4

Trimethylamine N-oxide and inflammatory disease
下载PDF
导出
摘要 体内高水平的肠道菌群代谢产物氧化三甲胺(trimethylamine N-oxide,TMAO)能够促进炎症性疾病的发生发展。本文就TMAO与糖尿病、动脉粥样硬化和心力衰竭等炎症性疾病的关系以及TMAO引起炎症性疾病的潜在分子机制予以综述。 High levels of intestinal flora metabolite Trimethylamine N-oxide can promote the development of inflammatory diseases.This reviews mainly discussed the relationship between the TMAO and inflammatory diseases,such as diabetes,atherosclerosis,heart failure and the potential molecular mechanisms of TMAO-induced inflammatory diseases.
作者 方青 欧阳冬生 FANG Qing;OU-YANG Dongsheng(Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha 410008,Hunan,China;Institute of Clinical Pharmacology,Central South University,Hunan Key Laboratory of Pharmacogenetics,Changsha 410078,Hunan,China;Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples,Changsha 410000,Hunan,China)
机构地区 中南大学湘雅医院临床药理研究所 中南大学临床药理研究所 复杂基质样本生物分析湖南省重点实验室
出处 《中国临床药理学与治疗学》 CAS CSCD 2019年第3期318-326,共9页 Chinese Journal of Clinical Pharmacology and Therapeutics
基金 国家科技重大专项基于药物基因组学的示范性新药临床评价技术平台建设项目(2017ZX090361) 复杂基质样本生物分析湖南省重点实验室项目(2017TP1037)
关键词 肠道菌群 氧化三甲胺 炎症性疾病 益生菌 gut microbiota trimethylamine-N-oxide inflammatory disease probiotics
分类号 R364.5 [医药卫生—病理学]
  • 相关文献

参考文献7

二级参考文献346

  • 1WELLEN K E,HOTAMISLIGIL G S.Obesity-induced inflammatory changes in adipose tissue[J].J Clin Invest,2003,112 (12):1785-1788.
  • 2DANDONA P,ALJADA A,MOHANTY P,et al.Insulin inhibits intranuclear nuclear factor kappa B and stimulates I-kappa B in mononuclear cells in obese subjects:evidence for an anti-inflammatory effect[J]? J Clin Endocrinol Metab,2001,86 (12):3257-3265.
  • 3ALJADA A,GHANIM H,MOHANTY P,et al.Insulin inhibits the proinflammatory transcription factor early growth response gene-1 (Egr) -1 expression in mononuclear cells (MNC) and reduces plasma tissue factor(TF) and plasminogen activator inhibitor-1 (PAI-l) concentrations[J].J Clin Endocrinol Metab,2002,87 (3):1419-1422.
  • 4TAKEBAYASHI K,ASO Y,INUKAI T.Initiation of insulin therapy reduces serum concentrations of high-sensitivity C-reactive protein in patients with type2 diabetes[J].Metabolism,2004,53 (6):693-699.
  • 5STENTZ FB,UMPIERREZ GE,CUERVO R,et al.Proinflammatory cytokines,markers of cardiovascular risks,oxidative stress,and lipid petoxidation in patients with hyperglycemic crises[J].Diabetes,2004,53(8):2079-2086.
  • 6JESCHKE M G,KLEIN D,BOLDER U,et al.Insulin attenuates the systemic inflammatory response in endotoxemic rats[J].Endocrinology,2004,145 (9):4084-4093.
  • 7JESCHKE M G,EINSPANIER R,KLEIN D,et al.Insulin attenuates the systemic inflammatory response to thermal trauma[J].Mol Med,2002,8 (8):443-450.
  • 8HOTAMISLIGIL G S.Inflammatory pathways and insulin action[J].Int J Obes Relat Metab Disord,2003,27 (Suppl 3):S53-S55.
  • 9SENN J J,KLOVER P J,NOWAK I A,et al.Suppressor of cytokine signaling-3 (SOCS-3),a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes[J].J Biol Chem,2003,278 (16):13740-13746.
  • 10EMANUELLI B,PERALDI P,FILLOUX C,et al.SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice[J].J Biol Chem,2001,276 (51):47944-47949.

共引文献220

同被引文献88

引证文献4

二级引证文献9

中国临床药理学与治疗学
2019年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部