疏血通注射液对脓毒症休克患者肾功能的影响

Effect of Shuxuetong injection on renal function in patients with septic shock

目的分析疏血通注射液对脓毒症休克患者肾功能的影响及治疗效果。方法脓毒症休克患者80例按入院顺序随机分为治疗组和对照组,每组40例,2组均给予常规基础治疗,治疗组加用疏血通注射液,共用7 d。比较2组临床疗效,并检测2组治疗前后的血乳酸(LAC)、尿素氮(BUN)、肌酐(SCr)、尿量及多巴胺、多巴酚丁胺、去甲肾上腺素用量,统计2组的28 d病死率。结果治疗组总有效率为72.5%,高于对照组的40.0%(X^2=7.12,P<0.05)。治疗组和对照组患者治疗后LAC分别为(3.83±1.65)mmol/L和(4.72±2.25)mmol/L、BUN分别为(7.1±2.7)mmol/L和(9.3±3.5)mmol/L、SCr分别为(73.9±16.2)μmol/L和(95.7±15.8)μmol/L、尿量分别为(112.1±39.8)ml/h和(73.3±28.5)ml/h,2组比较均有统计学差异(t=2.114、2.651、2.337、2.332,P<0.05);治疗组和对照组患者治疗中多巴胺用量分别为(993.1±261.7)mg和(1 340.9±356.4)mg、多巴酚丁胺用量分别为(776.2±281.0)mg和(1 049.2±364.3)mg、去甲肾上腺素用量用量分别为(56.4±34.6)mg和(107.6±51.3)mg,2组比较有统计学差异(t=2.223、2.312、2.286,P<0.05);治疗组和对照组患者28 d病死率分别为41.1%和58.9%,2组比较有统计学差异(X^2=6.13,P<0.05)。结论疏血通注射液可以改善脓毒症休克患者的肾脏灌注,降低患者的病死率。

Objective To analyze the effect of Shuxuelong injection on renal function in patients with sepsis shock.Methods Eithgy patients with septic shock were randomly divided into treatment group and control group,40 cases in each group,the 2 groups were given conventional treatment,the treatment group were treated with Shuxuetong injection for 7 d.Clinical efficacy of 2 groups were compared,and detected the blood lactate(LAC),blood urea nitrogen(BUN),serum creatinine(SCr),urine volume and dopamine,dobutamine,norepinephrine dosage before and after treatment in the 2 groups,and analyzed the 28 d mortality rate of the 2 groups.Results In the treatment group,the total effective rate was 72.5%,higher than the control group of 40.0%(x^2 =7.12,P <0.05).Treatment group and control group patients after treatment,LAC were(3.83 ±1.65) mmol / L and(4.72 ±2.25) mmol/L,respectively;BUN were(7.1 ±2.7) mmol/L and(9.3 ±3.5)mmol/L,respectively;SCr were(73.9 ± 16.2) mmol/L and(95.7 ± 15.8) mmol/L,respectively;urine volume were(112.1 ± 39.8) ml/h and(73.3 ± 28.5) ml/h,respectively;there were statistically differences of these index between the 2groups(t = 2.214,t =2.651,t =2.337,t =2.332,P <0.05);treatment group and control group patients' usage of dopamine were(993.1 ± 261.7) mg and(1 340.9±356.4) mg,the dobutamine dosage were(776.2 ± 281.0) mg and(1 049.2±364.3) mg,norepinephrine dosage were(56.4±34.6) mg and(107.6±51.3) mg,there was statistical differences of these usage between the two groups(t =2.223,1=2.312,t = 2.286,P <0.05);the treatment group and the control groups' 28 d mortality were 41.1%and 58.9%.there were significandy different(x^2 =6.13,P <0.05).Conclusion It demonstrated that the Shuxuetong injection may improve renal perfusion in patients with septic shock,reduce patient' s mortality.