1Kopelman PG.Obesity as a medical problem.Nature,2000,404:635-643.
2Jéquier E.Energy expenditure in obesity.Clin Endocrinol Metab,1984,13:563-580.
3O' Rahilly S.Human genetcs illuminates the paths to metabolic disease.Nature,2009,462:307-314.
4Lissner L.Measuring food intake in studies of obesity.Public Health Nutr,2002,5:889-892.
5Jackson RS,Creemers JW,Ohagi S,et al.Obesity and impaired prohormone procecessing associated with mutations in the human prohormone convertase 1 gene.Nature Genet,1997,16:303-306.
6Zhang Y,Proenca R,Maffei M,et al.Positional cloning of the mouse obese gene and its human homologue.Nature,1994,372:425-432.
7Huszar D,Lynch CA,Fairchild-Huntress V,et al.Targeted disruption of the melanocortin-4 receptor results in obesity in mice.Cell,1997,88:131-141.
8O' Rahilly S,Farooqi IS.Human obesity:a heritable neurobehavioral disorder that is highly sensitive to environmental conditions.Diabetes,2008,57:2905-2910.
9Krakoff J,Ma L,Kobes S,et al.Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.Diabetes,2008,57:3267-3272.
10Nogueiras R,Wiedmer P,Perez-Tilve D,et al.The central melanocortin system directly controls peripheral lipid metabolism.J Clin Invest,2007,117:3475-3488.