顽痹清丸治疗湿热痹阻证强直性脊柱炎33例临床研究

Clinical Observation on 33 Cases of Ankylosing Spondylitis Treated by Wanbiqing Pill Combined with Sulfasalazine

目的:观察顽痹清丸联合柳氮磺吡啶治疗强直性脊柱炎的临床疗效。方法:将72例强直性脊柱炎患者随机分为治疗组和对照组,每组36例。对照组患者口服柳氮磺吡啶片,治疗组患者在对照组基础上予以顽痹清丸口服,12周为1个疗程。比较两组患者治疗前后血沉、C反应蛋白、IL-33等实验室指标,VAS评分变化情况以及临床疗效,同时回访记录并比较两组患者不良反应发生情况。结果:治疗过程中两组各脱落3例,最终各入组33例。治疗组患者治疗12周后实验室检查指标、VAS评分及临床疗效均优于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:顽痹清丸联合柳氮磺吡啶治疗强直性脊柱炎疗效显著,优于单纯口服柳氮磺吡啶,可显著控制患者病情,改善其生活质量。

Objective:To observe the clinical efficacy of Wanbiqing Pills combined with Sulfasalazine(SSZ)on treatment of Ankylosing Spondylitis(AS).Methods:72 patients with ankylosing spondylitis were randomly divided into a treatment group and a control group,36 in each group.The control group received SSZ and Celebrex treatment while the treatment group was given Wanbiqing Pill on the basis of the control group.The ESR,CRP,IL-33,VAS scores and syndrome scores were compared between the two groups before treatment and at 12 weeks after treatment.Adverse reactions were also recorded.Results:The levels of ESR,CRP,IL-33 in both two groups were lower than both those before treatment and that in control group after treatment;The VAS scores and clinical efficacy in treatment group were better than that in control group before treatment and after treatment,the difference was statistically significan.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:Wanbiqing Pill combined with SSZ on treatment of AS have a good curative effect,which is better than treatment of oral SSZ only.It can significantly control disease activity and improve patients’ quality of life.