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MicroRNA-126 inhibits the proliferation of lung cancer cell line A549 被引量：4

MicroRNA-126 inhibits the proliferation of lung cancer cell line A549
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摘要 Objective:To study the role of microRNA-126 in the development of lung cancer.Methods:The biological function of microRNA-126 was delected using EdU assay and CCK-8 assay:the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot assay.Results:In A549 cell line,overexpression of microRNA-126 inhibils the prolileralion rate:VEGF is the target gene of microRNA-126:microRNA-126 exerts its function via regulating VEGF protein level.Conclusions:microRNA-126 inhibits the proliferation in A549 cell line. Objective:To study the role of microRNA-126 in the development of lung cancer.Methods:The biological function of microRNA-126 was delected using EdU assay and CCK-8 assay:the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot assay.Results:In A549 cell line,overexpression of microRNA-126 inhibils the prolileralion rate:VEGF is the target gene of microRNA-126:microRNA-126 exerts its function via regulating VEGF protein level.Conclusions:microRNA-126 inhibits the proliferation in A549 cell line.
作者 Xun Yang Bei-Bei Chen Ming-Hua Zhang Xin-Rong Wang
机构地区 Respiratory Department
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2015年第3期239-242,共4页 亚太热带医药杂志（英文版）
基金 supported by National Natutal Science Foundation of China(81073036)
关键词 microRNA-126 PROLIFERATION VEGF microRNA-126 Proliferation VEGF
分类号 R734.2 [医药卫生—肿瘤]
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参考文献9

  • 1M. Crawford,E. Brawner,K. Batte,L. Yu,M.G. Hunter,G.A. Otterson,G. Nuovo,C.B. Marsh,S.P. Nana-Sinkam.MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines[J]. Biochemical and Biophysical Research Communications . 2008 (4)
  • 2Alla Musiyenko,Vira Bitko,Sailen Barik.Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells[J]. Journal of Molecular Medicine . 2008 (3)
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Asian Pacific Journal of Tropical Medicine
2015年 第3期

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