期刊文献+

Expression of HIP/PAP in hepatocellular carcinoma and effect of siRNA on migration and invasion in HCC cells 被引量:1

Expression of HIP/PAP in hepatocellular carcinoma and effect of siRNA on migration and invasion in HCC cells
下载PDF
导出
摘要 Objective:To investigate the expression of HIP/PAP in hepatocellular carcinoma(HCC)patients and explore its role in migration and invasion of HCC.Methods:The expression of HIP/PAP in HCC tissue and corresponding adjacent noncancerous tissue was assessed by IHC,RT-PCR and Western blot.The correlation between clinicopathological features and HIP/PAP expression was analyzed.The role of HIP/PAP on invasion and migration of HCC cells was observed by RNA interference,wound healing and Transwell assay.Results:Both mRNA and protein expression of HIP/PAP was upregulated in HCC tissues compared to tumor-adjacent tissue and correlated with poor tumor differentiation,advanced tumor stage and vascular invasion.HIP/PAP expression was also upregulated in HCC cells,and silencing its expression by specific siRNA could inhibit the invasion and migration of HCC cells.Conclusions:HIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells. Objective:To investigate the expression of HIP/PAP in hepatocellular carcinoma(HCC)patients and explore its role in migration and invasion of HCC.Methods:The expression of HIP/PAP in HCC tissue and corresponding adjacent noncancerous tissue was assessed by IHC,RT-PCR and Western blot.The correlation between clinicopathological features and HIP/PAP expression was analyzed.The role of HIP/PAP on invasion and migration of HCC cells was observed by RNA interference,wound healing and Transwell assay.Results:Both mRNA and protein expression of HIP/PAP was upregulated in HCC tissues compared to tumor-adjacent tissue and correlated with poor tumor differentiation,advanced tumor stage and vascular invasion.HIP/PAP expression was also upregulated in HCC cells,and silencing its expression by specific siRNA could inhibit the invasion and migration of HCC cells.Conclusions:HIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells.
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2015年第10期830-834,共5页 亚太热带医药杂志(英文版)
基金 supported by grant from Program for Science and Technology Development of Jiangsu Province(YG201503)
关键词 HEPATOCELLULAR CARCINOMA HIP/PAP Prognosis Migrati Hepatocellular carcinoma HIP/PAP Prognosis Migrati
  • 相关文献

参考文献16

  • 1Jun Wang,Hong Zhou,Yong Han,Xiulan Liu,Min Wang,Xin Wang,Guoxiao Yin,Xu Li,Ming Xiang.SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer[J]. Journal of Molecular Medicine . 2014 (12)
  • 2Atle Beelen Granlund,Ann Elisabet ?stvik,?ystein Brenna,Sverre H. Torp,Bj?rn I. Gustafsson,Arne Kristian Sandvik.REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation[J]. Cell and Tissue Research . 2013 (3)
  • 3The inflammatory microenvironment of HCC – The plot becomes complex[J]. Journal of Hepatology . 2010 (5)
  • 4Chiara Porta,Paola Larghi,Monica Rimoldi,Maria Grazia Totaro,Paola Allavena,Alberto Mantovani,Antonio Sica.Cellular and molecular pathways linking inflammation and cancer[J]. Immunobiology . 2009 (9)
  • 5Valérie Hervieu,Laurence Christa,Géraldine Gouysse,Raymonde Bouvier,Jean-Alain Chayvialle,Christian Bréchot,Jean-Yves Scoazec.HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors[J]. Human Pathology . 2006 (8)
  • 6Morris Sherman.Hepatocellular Carcinoma: Epidemiology, Risk Factors, and Screening[J]. Semin Liver Dis . 2005 (02)
  • 7Lasserre C,Simon M T,Ishikawa H,Diriong S,Nguyen V C,Christa L,Vernier P,Brechot C.Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. European journal of biochemistry / FEBS . 1994
  • 8Nicolas Moniaux,Marion Darnaud,Alexandre Dos Santos.HIP/PAP, a new drug for acute liver failure. M S-MEDECINE SCIENCES . 2012
  • 9Mukherjee S,Zheng H,Derebe MG,Callenberg KM,Partch CL,Rollins D,Propheter DC,Rizo J,Grabe M,Jiang QX,Hooper LV.Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature . 2014
  • 10Cavard C,Terris B,Grimber G,Christa L,Audard V,Radenen-Bussiere B,Simon M-T,Renard C-A,Buendia M-A,Perret C.Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. Oncegene . 2005

共引文献1

同被引文献10

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部