家兔自体移植段颈总动脉前列环素和cAMP含量的研究

THE GENERATION OF PROSTACYCLIN AND CYCLIC AMP BY CAROTID ARTERY AUTOGRAFT IN RABBTS

对家兔颈总动脉进行自体原位移植,观察移植2周后前列环素(PGI_2)和 cAMP 含量,结果自体移植段动脉 PGI_2含量为50.105±26.131pg/mg(±s),比完整段动脉的21.684±12.875pg/mg 明显增加(P<0.05);移植段动脉 cAMP 含量为2.080±1.535pmol/mg,比完整段0.172±0.099pmol/mg 也有明显增加(P<0.05)。这提示移植段动脉 PGI_2含量的增加有抗动脉粥样硬化(动粥)的作用,并对其机理以及与 cAMP 相互关系作了讨论。

It demonstrates in present investigation that 6-tone-PGF_1αcontent(50.105±26.131 pg/ rag)in the segments of autograft is more than in the segments of intact(21.684±12.875pg/ rag)(P<0.05);cAMP content(2.080±1.535pmol/mg)in the segments of autograft is more than in segments of in intact(0.172±0.0990pmol/mg)as well(P<0.05).This result indi- cates that elevation of prostacyclin in the segments of artery autograft helps to protect atheroscle- rosis.The mechanism of prostacyclin to be elevated and the relation of it with cAMP has been dis- cussed.