施氏温针对神经根型颈椎病炎症状况内皮素丙二醛水平的影响及其机制分析

Effects of Shi′s warm-needle acupuncture on inflammatory condition and levels of ET and MDA in patients with cervical spondylotic radiculopathy and its mechanism

目的研究施氏温针对神经根型颈椎病(CSR)炎症状况、内皮素(ET)、丙二醛(MDA)水平的影响及其机制。方法回顾性分析2017年4月至2018年3月在我院就诊的CSR患者88例,按照治疗方式不同,分为研究组(46例)和对照组(42例)。对照组采用普通针灸配合穴位贴敷治疗,研究组采用施氏温针配合穴位贴敷治疗,分析比较2组患者炎症状况及ET、MDA水平。结果研究组和对照组治疗有效率分别为93.48%和78.57%,2组比较差异有统计学意义(P<0.05)。治疗后,2组简化麦吉尔(McGill)疼痛评分较治疗前均明显降低,且研究组McGill疼痛评分明显低于对照组(P<0.05)。治疗后,2组血清超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6和肿瘤坏死因子(TNF)-α水平明显低于治疗前,且研究组hs-CRP、IL-6和TNF-α水平明显低于对照组(P<0.05)。治疗后,2组血清ET、MDA水平明显低于治疗前(P<0.05),且研究组ET、MDA水平明显低于对照组(P<0.05)。结论施氏温针配合穴位贴敷治疗神经根型颈椎病患者疗效确切,可明显改善炎症状况,降低血清ET、MDA水平,缓解疼痛症状,值得临床推广。

Objective To investigate the effects of warm-needle acupuncture on the inflammatory condition and levels of endothelin(ET) and malonaldehyde(MDA) in patients with cervical spondylotic radiculopathy(CSR) and its mechanism. Methods The clinical data of 88 CSR patients admitted to our hospital between April 2017 and March 2018 were retrospectively analyzed. According to different treatment methods, all patients were divided into the study group(n=46) and control group(n=42). The control group was treated with general acupuncture combined with acupoint sticking therapy, and the study group was treated with Shi′s warm-needle acupuncture combined with acupoint sticking therapy. The inflammatory condition and levels of ET and MDA in the two groups were analyzed and com-pared. Results The clinical effective rate in the study group and the control group was 93.48% and 78.57%, respec-tively, with statistically significant difference between the two groups(P<0.05). After the treatment, the McGill pain scores in the two groups were significantly lower than those at the baseline, and the McGill pain scores in the study group were significantly lower than those in the control group(P<0.05). After the treatment, the levels of high-sensitivity C-reactive protein(hs-CRP), interlukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in the two groups were lower than those at the baseline, and the levels of hs-CRP, IL-6 and TNF-α in the study group were lower than those in the control group(P<0.05). After the treatment, the levels of ET and MDA in the two groups were significantly lower than those at the baseline(P<0.05), and levels of ET and MDA in the study group were significantly lower than those in the control group(P<0.05). Conclusion Shi′s warm-needle acupuncture combined with acupoint sticking therapy is effective in the treatment of CSR, which may significantly improve the inflammatory condition, reduce the levels of serum ET and MDA, and relieve pain symptoms, and therefore is worthwhile of widespread use in clinical practices.