术后重度疼痛患者使用镇痛药物的经济学评价

Pharmacoeconomic Analysis of Analgesics in Patients with Severe Pain After Operation

目的:对两种术后镇痛方案进行药物经济学评价,为临床合理用药提供指导。方法:回顾性分析胸外科开胸术后重度疼痛患者使用静脉自控镇痛泵(patient controlled intravenous analgesia,PCIA)治疗的情况,87例病例根据镇痛药物分为A组(地佐辛+右美托咪定+托烷司琼)和B组(地佐辛+布托啡诺+托烷司琼),用药48 h后观察镇痛疗效和药品不良反应,并采用成本-效果分析方法对两组治疗方案进行药物经济学评价。结果:A、B两组疼痛缓解率分别为97. 78%,97. 62%,差异无统计学意义(P>0. 05)。各组均无严重药品不良反应出现,药品不良反应发生率分别为13. 33%,4. 76%,差异无统计学意义(P>0. 05)。A、B组人均成本分别为1 092. 14,729. 91元,成本-效果比分别为11. 17,7. 48。结论:手术48 h后,两组方案疼痛缓解率相当,B组花费较低,且药品不良反应发生率也较低。

Objective:To explore the cost-effectiveness of two analgesic regimens for analgesia after thoracic surgery,and then to provide guidance for rational drug use in clinical practice.Methods:87 patients were treated with patientcontrolled intravenous analgesia(PCIA)and divided into Group A(desozin+dexmedetomidine+tropisetron)and Group B(desozin+butorphanol+tropisetron)in light of the medication in the analgesic pump to find out their reactions after taking 48 hours analgesic treatment and to conduct a pharmacoeconomic analysis of the cost-effectiveness of the two treatment options.Results:The pain relief rates of Group A and Group B were 97.78%and 97.62%respectively,and there was no significant difference between the two groups(P>0.05).The rates of adverse reactions in Group A and Group B were 13.33%and 4.76%respectively(P>0.05),mainly represented by hypotension,nausea and vomiting.The costs per capita in Group A and Group B were 1 092.14 and 729.91 respectively,and the cost-effectiveness ratios were 11.17 and 7.48 respectively.Conclusion:Based on these findings,there was no significant difference in pain relief rate between the two groups within 48 hours after surgery and Group B cost less money and witnessed fewer adverse reactions.