比阿培南注射剂专项点评方法的构建及应用

Construction and Application of Special Evaluation Method for Biapenem Injection

目的:建立一种比阿培南的药物利用评价标准和评价方法,为其他抗菌药物的专项点评提供借鉴。方法:抽取某院2017年7月~2018年6月临床使用比阿培南的病历271份,采用基于限定日剂量(DDD)/限定日浓度(DDC)的药物利用评价方法和基于属性层次(AHM)的加权逼近理想解排序法(TOPSIS)分别评价比阿培南临床使用的合理性。结果:基于DDD/DDC的药物利用评价结果显示,比阿培南临床使用剂量基本合理,存在超浓度给药的现象。全年均值显示,平均用药频度(aDDDs/aDDCs)=0.673 0/2.692 2,药物利用指数(dDUI/cDUI)=0.840 2/3.361 0,采用DDC评价某药临床使用合理性比DDD更敏感。基于AHM的加权TOPSIS法研究结果显示,271份使用比阿培南的病历中,合理病历110份(40.59%),基本合理病历115份(42.43%),不合理病历46份(16.97%)。结论:建立的评价方法可有效评价比阿培南临床使用合理性,值得进一步研究和推广应用。

Objective:To establish a drug utilization evaluation standard and evaluation method for biapenem,and provide reference for the special evaluation of other antibiotics.Methods:271 electronic medical records of Biapenem in a hospital from July 2017 to June 2018 were collected.The rationality of Biapenem in clinical use was evaluated by defined daily dose(DDD)/defined daily concentration(DDC)and AHM-based weighted TOPSIS.Results:Based on DDD/DDC drug utilization evaluation results,the clinical dose of biapenem was basically reasonable,and there was a phenomenon of over-concentration administration(annual average showed aDDDs/aDDCs=0.673 0/2.692 2,dDUI/cDUI=0.840 2/3.361 0).The use of DDC to evaluate the rationality of a clinical use of a drug was more sensitive than a DDD.AHM-based weighted TOPSIS study showed that 271 cases of biapenem had a reasonable medical record of 110(40.59%),a basically reasonable medical record of 115(42.43%),and an unreasonable medical record of 46(16.97%).Conclusion:This evaluation method can effectively evaluate the rationality of clinical use of drugs,and it is worthy of further research and application.