宁泌泰胶囊对大鼠大肠杆菌感染性盆腔炎的改善作用研究

Experiment research on therapeutic effect of Ningmitai Capsule for pelvic inflammation

目的探究宁泌泰胶囊对盆腔炎病症的改善作用。方法选用大鼠大肠杆菌感染性盆腔炎模型,苯酚胶浆引起大鼠化学性盆腔炎模型,用妇科千金片(1.0 g/kg)及宁泌泰胶囊高、中、低剂量(2.0、1.0、0.5 g/kg)连续ig 7 d,每天2 次。以动物体质量变化、白细胞计数、病理学检查评价宁泌泰胶囊对盆腔炎的治疗作用。结果宁泌泰胶囊 3 个剂量组对大肠杆菌引起的感染性盆腔炎大鼠子宫肉眼可见的炎性症状有一定的改善作用,可不同程度地抑制炎症引起的血中白细胞的数量升高,并且能改善炎症引起的体质量下降。宁泌泰胶囊高、中(2.0、1.0 g/kg)剂量组可显著减轻子宫的质量,提示抑制炎症引起的肿胀。子宫组织病理学检查结果表明,宁泌泰胶囊可改善大肠杆菌感染引起的大鼠子宫组织学病变,且有一定的剂量相关性。对于苯酚胶浆引起的大鼠盆腔炎,宁泌泰胶囊3 个剂量组均能改善炎症引起的体质量下降。宁泌泰胶囊高剂量组(2.0g/kg)可显著抑制炎症引起的血中白细胞的数量升高,并且可显著减轻子宫的质量,提示抑制炎症引起的肿胀。子宫组织病理学检查结果表明,宁泌泰胶囊可改善苯酚胶浆引起的大鼠子宫组织学病变,且有一定的剂量相关性。结论宁泌泰胶囊对于化学性和细菌性等多种因素引起的盆腔炎动物模型的相关症状具有明显的改善作用。

Objective To investigate the therapeutic effect of Ningmitai Capsule for pelvic inflammation. Methods Using pelvic inflammation model induced by coliform and phenol in rats, the model mice were ig administrated with Qianjin Formula (1 g/kg) and Ningmitai Capsule (2, 1, and 0.5 g/kg). All rats and rabbits were fed for 7 d. The body weight, amount of WBC, histological lesions were determined to evaluate the therapeutic effect of Ningmitai Capsule for uterus. Results Pelvic inflammation model induced by coliform in rats could significantly reduce the number of leukocytes in blood and improve weight loss caused by inflammation. The histopathology results showed that Ningmitai Capsule could improve histological lesions of pelvic inflammation. There are certain contacts of efficacy and dose. In addition, pelvic inflammation induced by phenol in rats, Ningmitai Capsule (2.0 g/kg) can significantly reduce the number of leukocytes in the blood. The histopathology results showed that Ningmitai Capsule could improve histological lesions in vagin. Conclusion Ningmitai Capsules have significant effects on symptoms of pelvic inflammation induced by a variety of bacterial and chemical factors.