甲磺酸倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果及安全性分析

Clinical efficacy and safety of Flunarizine hydrochloride combined with Betahistine mesylate in treatment of tinnitus

目的探讨甲磺酸倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果及安全性。方法选取2016年1月—2017年12月西宁市第一人民医院收治的耳鸣患者178例,按照治疗方法的不同分为对照组、观察组,每组89例。对照组给予盐酸氟桂利嗪进行治疗,5 mg/次,1次/d,疗程2周。观察组在对照组基础上联合甲磺酸倍他司汀进行治疗,12 mg/次,3次/d,疗程2周。比较两组的临床疗效、治疗前后耳鸣程度、听力水平及治疗期间不良反应的发生情况。结果观察组临床疗效的总有效率(87.64%)显著高于对照组(42.70%),差异有统计学意义(P<0.05)。治疗前两组患者的耳鸣评分差异不显著,治疗后两组患者的耳鸣评分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组显著低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者的听力水平差异不显著;治疗后两组患者的听力均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组显著低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率差异不显著。结论甲磺酸倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果优于单纯使用盐酸氟桂利嗪,安全可靠,值得临床应用与推广。

Objective To explore the clinical efficacy and safety of flunarizine hydrochloride combined with betahistine mesylate in the treatment of tinnitus.Methods Selected 178 tinnitus patients in our hospital from January 2016 and December 2017. All patients were divided into control group and observation group, 89 cases in each group. The control group was treated with flunarizine hydrochloride, and the observation group was treated with Betahistine mesylate. The clinical efficacy, degree of tinnitus, hearing level before and after treatment, and occurrence of adverse reactions during treatment were compared between the two groups. Results The total effective rate of clinical efficacy in the observation group (87.64%) was significantly higher than that of the control group (42.70%) (P < 0.05). There was no significant difference in tinnitus score between the two groups before treatment. After treatment, the tinnitus scores of both groups were significantly lower (P < 0.05), and the observation group was significantly lower than the control group (P < 0.05). There was no significant difference in hearing between the two groups before treatment. After the treatment, the hearing loss of both groups was significantly lower (P < 0.05), and the observation group was significantly lower than the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups.Conclusions Flunarizine hydrochloride combined with betahistine mesylate is superior to flunarizine hydrochloride in the treatment of tinnitus. It is safe and reliable and worthy of clinical application and promotion.