注射用丹参多酚酸联合甲磺酸倍他司汀片治疗后循环缺血性眩晕的疗效

Therapeutic effect of Salvianolic Acids for Injection combined with Betahistine Mesilate Tabletsfor in treatment of posterior circulation ischemic vertigo

目的观察注射用丹参多酚酸联合甲磺酸倍他司汀片治疗后循环缺血性眩晕病人的临床疗效。方法将96例患者随机分为2组,各48例,对照组采取常规治疗,口服甲磺酸倍他司汀片,6 mg/次,3次/d,观察组加用注射用丹参多酚酸治疗,0.13 g加入到0.9%氯化钠注射液250 mL中静滴,1次/d,14 d后比较两组椎基底动脉供血和血流变指标、临床疗效和不良反应。结果观察组治疗后椎基底动脉血流速度(收缩期峰流速、舒张期末流速、平均流速)和血流变学指标(全血比黏度、血浆比黏度、纤维蛋白原)改善情况明显优于治疗前,且治疗后观察组优于对照组的,差异具有统计学意义(P<0.05);观察组痊愈率和总有效率均明显高于对照组,差异具有统计学意义(P<0.05),且两组均无不良反应发生。结论注射用丹参多酚酸联合甲磺酸倍他司汀片治疗椎后循环缺血性眩晕具良好的疗效,值得临床推广应用。

Objective To observe the clinical effect of Salvianolic Acids for Injection(SAFI) combined with Betahistine Mesilate Tablets(BMT) in the treatment of posterior circulation ischemic vertigo(PCIV). Methods In the 96 cases, patients with PCIV were randomly divided into observation group(n = 48) and control group(n = 48). Patients in the control group were given conventional therapy and oral BMT 6 mg tid, while the observation groups were treated by BMT combined with 0.13 g SAFI added for 250 mL0.9% sodium chloride intravenous drip qd. After all patients in the two groups treated for 14 d, the blood flow velocity of vertebrobasilar artery, hemorheological indexes, clinical efficacy, and adverse reactions of two groups were compared. Results After treatment, the blood flow velocity of vertebrobasilar artery(Vs, Vd, Vm), and hemorheological indexes(whole blood viscosity,plasma viscosity, fibrinogen) in the observation groups were significantly improved than those before treatment, the observation groups was significantly improved than control groups, and the difference was statistically significant(P < 0.05). The recovery rate and total efficiency of the observation groups were significantly higher than the control groups(P < 0.05), and there were no ADR patients in both groups. Conclusions SAFI combined with BMT in the treatment of PCIV has a good effect and is worthy of clinical application.