肿瘤代谢重排与肿瘤耐药相关性的研究进展

Advances in studies on relationship between tumor metabolic rearrangement and tumor chemotherapy resistance

肿瘤细胞的代谢重编程被认为是肿瘤的十大特征之一。肿瘤组织通过代谢重编程以满足肿瘤快速生长对生物能量、生物合成和氧化还原的需求。伴随着肿瘤代谢重编程,细胞内外的一些代谢产物对基因表达、细胞分化和肿瘤微环境均具有深远的影响。其中最显著的变化包括糖酵解的激活、脂质代谢的增加、线粒体生物合成增强以及磷酸戊糖通路的激活。代谢重编程不仅发生在正常细胞向肿瘤细胞转化的过程中,也发生在晚期肿瘤细胞的发育过程中,与抗癌药物的敏感性有很密切的关系。因此,化疗药物联合细胞代谢抑制剂可能是一种有望克服肿瘤耐药的策略。从这个角度讨论肿瘤细胞代谢与肿瘤耐药的关系,并总结出失调的代谢通路可以作为潜在的肿瘤治疗靶点,来抑制对常规治疗耐药的肿瘤。

Metabolic reprogramming of tumor cells is considered to be one of the ten features of tumors.It usually occurs in tumor tissues to meet the bioenergy,biosynthesis,and redox requirements for the rapid proliferation of tumors.With the reprogramming of tumor metabolism,some intracellular or extracellular metabolites have profound effects on gene expression,cell differentiation and tumor microenvironment.At the same time,tumor metabolism is also closely related to chemotherapy resistance.This review discusses the relationship between metabolism and chemoresistance,and we conclude that dysregulated metabolic pathways can be used as a potential therapeutic target to suppress the tumors that are resistant to conventional treatment.