贞芪扶正颗粒与顺铂和多西他赛化疗方案联用治疗宫颈癌的效果研究

Effect of cisplatin and docetaxel chemotherapy combined with Zhenqii Fuzheng Granule on cervical cancer

目的研究贞芪扶正颗粒与顺铂和多西他赛化疗方案联用治疗宫颈癌的效果。方法选择2015年1月—2017年12月漯河市郾城区中医院收治的61例宫颈癌患者,随机分为两组。对照组采用顺铂联合多西他赛化疗方案,观察组在对照组基础上联用贞芪扶正颗粒治疗。1个治疗周期为21 d,共治疗5个周期。比较两组的T细胞亚群指标变化情况、生存质量评分和毒副作用发生情况。结果观察组的有效率(76.67%)明显高于对照组(53.84%),差异有统计学意义(P<0.05)。对照组治疗前后的自然杀伤细胞(NK)、CD4^+、CD3^+及CD8^+相比无明显差异;观察组治疗后的T细胞亚群指标均明显优于治疗前和对照组,差异有统计学意义(P<0.05)。两组治疗后的生存质量卡氏(KPS)评分值均明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且观察组的KPS评分值明显高于对照组,差异有统计学意义(P<0.05)。观察组血小板降低、贫血、白细胞下降的发生率明显低于对照组,差异有统计学意义(P<0.05),两组的胃肠道反应、肝功能损伤、口腔炎以及肾功能损伤发生率相比无明显差异。结论在顺铂联合多西他赛化疗方案的基础上,联用贞芪扶正颗粒可以提高宫颈癌的治疗效果,增强患者的免疫功能,减少毒副作用的发生,提高生存质量。

Objective To study the effect of cisplatin and docetaxel chemotherapy combined with Zhenqi Fuzheng Granule on cervical cancer.Methods Selected 61 cases of patients with cervical cancer who were treated in our hospital from January 2015 to December 2017,divided into two groups randomly.The control group was treated with cisplatin plus docetaxel chemotherapy,and the observation group was treated with Zhenqi Fuzheng granule.Results After treatment,the effective rate of the observation group was significantly higher than control group(P<0.05).There was no significant difference in NK,CD4^+,CD3^+and CD8^+before and after treatment in the control group.The T cell subgroups of the observation group were significantly better than those before and in the control group(P<0.05).The KPS scores of the two groups were significantly higher after treatment(P<0.05),and the KPS score of the observation group was higher(P<0.05).The incidence of thrombocytopenia,anemia and leukocyte decline in the observation group was significantly lower than that of the control group(P<0.05).There was no significant difference in the incidence of gastrointestinal reaction,liver function injury,stomatitis and renal function injury in the two groups.Conclusion On the basis of cisplatin combined with docetaxel chemotherapy,combined use of Zhenqi Fuzheng granule can improve the therapeutic effect of cervical cancer,enhance the immune function of the patients,reduce the occurrence of toxic effects and improve the quality of life.